Among the other treatments available nowadays for erectile dysfunction, Viagra was the first. So Viagra has been emerging as a pioneer in erectile dysfunction drugs for twenty years. He made men confident again and revived husbands. Sildenafil citrate was the first oral agent offered to treat erectile dysfunction, thanks to researchers from Pfizer. Sildenafil is a highly selective PDE5 2,3-type inhibitor and enhances NO-mediated relaxation of the human corpus cavernosum. Sildenafil Viagra Cost, by inhibiting the enzyme phosphodiesterase, increases intracellular concentrations of 3,5-inch guanosine monophosphate (cGMP), causing amplification of the endogenous NO-cGMP signaling pathway. Considered a vasodilator, it works by increasing blood flow to the penis and thus restores impaired erectile function.

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